Dr S Mosebi

Expertise

• Diagnostics
• Drug Discovery
• Protein Biochemistry

Qualifications

• BSc (Biochemistry and Microbiology)
• BSc (Hons) (Biochemistry)
• MSc (Biochemistry)
• PhD (Biochemistry)

Currently teaching

• Biochemistry and genetics at undergraduate level.
• Protein biochemistry, structural biology at postgraduate level

Field of Specialisation

• HIV and cancer drug discovery
• Diagnostics
• Food security
• Waste  

Journal articles

• Shaakira Abrahams, Salerwe Mosebi, Muhammed Q. Fish, Maria A. Papathanasopoulos, Raymond Hewer (2018) Screening of the NIH Clinical Collection for inhibitors of HIV-1 integrase activity. South African Journal of Science. 114:(3/4) 
• Njengele Z., Kleynhans R., Sayed Y.,  Mosebi S (2016) Expression, purification and characterization of a full-length recombinant HIV-1 Vpu from inclusion bodies. Protein Expression and Purification, 128: 109–114.
• Harrison AT Kriel FH, Papathanasopoulos MA, Mosebi S, Abrahams S, Hewer R. (2015) The Evaluation of Statins as Potential Inhibitors of the LEDGF/p75- HIV-1 Integrase interaction. Chem. Biol. Drug Des. 85(3):290-5.
• Le Noury DA, Mosebi S, Papathanasopoulos MA and Hewer R. (2015) Functional roles of HIV-1 Vpu and CD74: details and implications of the Vpu-CD74 interaction. Cellular Immunology, 298: 25-32.
• MH Manyeruke, T Olomola, S Majumder, S Abrahams, M Isaacs, N Mautsa, S Mosebi, D Mnkandhlac, R Hewer, HC Hoppeb, R Klein, PT Kaye (2015) Synthesis and Evaluation of 3-Hydroxy-3-phenylpropanoate Ester-AZT Conjugates as Potential Dual-action HIV-1 Integrase and Reverse Transcriptase Inhibitors. Bioorganic and Medicinal Chemistry, 23: 7521-7528.
• Olomola TO, Mosebi S, Klein R, Traut-Johnstone T, Coates J, Hewer R, Kaye PT. (2014) Novel furocoumarins as potential HIV-1 integrase inhibitors. Bioorg. Chem. 57:1-4.
• Mphahlele M, Papathanasopoulos, Cinellu MA, Coyanis M, Mosebi S, Traut T, Modise R, Coates J and Hewer R. (2013). Modification of HIV-1 reverse transcriptase and integrase activity by gold (III) complexes in direct biochemical assays. Bioorg. Med.Chem. 20, 401 - 407.
• Mosebi S., Morris L., Dirr H. and Sayed, Y. (2008) Active Site Mutations in the South African HIV-1 Subtype C Protease Have a Significant Impact on Clinical Inhibitor Binding: a Kinetic and Thermodynamic Study. J. Virol. 82, 11476-11479.
• Kinsley N., Sayed Y., Mosebi S., Armstrong R. N. and Dirr H.W. (2008) Characterization of the binding of 8-anilinonaphthalene sulphonate to rat class Mu GST M1-1. Biophys. Chem.137, 100-104.
• Kuhnert D.C., Sayed Y., Mosebi S., Sayed M., Sewell T. and Dirr H. W. (2005) Tertiary Interactions Stabilise the C-Terminal Region of Human Glutathione Transferase A1-1: A Crystallographic and Calorimetric Study. J. Mol. Biol. 349, 825-838.
• Mosebi S., Sayed Y., Burke J. and Dirr H. W. (2003) Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions. Biochemistry. 42, 15326-15332.

    Scopus author ID 8632560900

    ORCID https://orcid.org/0000-0002-7028-1712

    Google Scholar https://scholar.google.co.za/citations?user=n44mYlUAAAAJ&hl=en&oi=ao