Covid-19 collection live on UnisaIR

The current crisis around the coronavirus (Covid-19) pandemic shows the importance of unrestricted access to scientific and scholarly information for researchers, students, journalists, and non-academic professionals.

A Covid-19 collection has been created in the Unisa Institutional Repository (UnisaIR) and has received its first submission from Professor Samantha Gildenhuys and the Personal Librarian, Dr Leslie Adriaanse. This article has been viewed from various national and international locations after less than 24 hours.

The viewing statistics of the collection have been captured below for more information. It is hoped that this will inspire Unisans to promote this collection to their clients so that the valued research outputs of the university may contribute to the international combatting of Covid-19.

The article can be viewed here and its title is as follows:

Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle

Gildenhuys, Samantha

URI: https://doi.org/10.1042/BCJ20200223
http://hdl.handle.net/10500/26441

Date: 2020

Type: Article

Abstract:

Coronavirus are the causative agents in many globally concerning respiratory disease outbreaks such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease-2019 (COVID-19). It is therefore important that we improve our understanding of how the molecular components of the virus facilitate the viral life cycle. These details will allow for the design of effective interventions. Krichel and coauthors in their article in the Biochemical Journal provide molecular details of how the viral polyprotein (nsp7–10) produced from the positive single stranded RNA genome, is cleaved to form proteins that are part of the replication/transcription complex. The authors highlight the impact the polyprotein conformation has on the cleavage efficiency of the main protease (Mpro) and hence the order of release of non-structural proteins 7–10 (nsp7–10) of the SARS-CoV. Cleavage order is important in controlling viral processes and seems to have relevance in terms of the protein–protein complexes formed. The authors made use of mass spectrometry to advance our understanding of the mechanism by which coronaviruses control nsp 7, 8, 9 and 10 production in the virus life cycle.

Citation: Biochemical Journal (2020) 477 1479–1482 https://doi.org/10.1042/BCJ20200223

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*By Natalia Molebatsi, Marketing Coordinator, Unisa Library

Covid-19 image by FrankundFrei from Pixabay