Department of Chemistry

MM Nindi

College of Science, Engineering and Technology
School of Science
Department: Chemistry
Professor
Tel: 011 670 9303
Fax: 012 429 8549
E-mail: nindimm@unisa.ac.za

Qualifications

  • PhD (KU)
  • MSc (WSU)
  • BSc Hons (WSU)

Fields of academic interests

  • Analytical Chemistry
  • Separation Science
  • Mass Spectometry and Sample Preparation

Other

Courses

  • CHE3704 - Analytical Chemistry III
  • CHE4804 - Advanced Analytical Chemistry (Honours)
  • CHE4807 - Environmental Chemistry (Honours)

Research:
My research interests can be subdivided into three categories:

Food safety, here interested in developing rapid, selective and sensitive methods of detection and characterisation of chemic origin. The vetinary al and veterinary drug residues in foods of animal origin.  The veterinary drugs of interest include antibiotics, developing rapid, selective and sensitive methods of detection and characterisation of chemic origin. The vetinary al and veterinary drug residues in foods of animal origin.  The veterinary drugs of interest include antibiotics, anthelmintics, anabolic steroids, that are commonly abused for animal producing industry for financial benefit.  Many of these compounds are a health hazard to consumers if consumed as residues in foods.  We continue to develop methods for known and unknown compounds as the challenges of food safety requires the enforcer to be on the fore front in detection of newly developed drugs.   In our research we incorporate sample preparation (dispersive liquid-liquid microextraction, Supported Liquid Membrane, Solid Phase Extraction), mass spectrometry, and LC-MS as our major tool.

We are also interested in phytochemistry and ethnopharmacology to provide biological and chemical information on indigenous plants especially secondary metabolites.  As analytical chemists we are interested in using analytical tools in isolating some important metabolites from plants and quantitatively determining their composition.  One of our recent projects is Devil’s claw project.  Commercial Devil’s Claw product has been package and sold without an indication of the percentage of active components given. We have successfully developed a quality control protocol for this product.  We are also interested in designing appropriate protocols for the quality control of other indigenous herbal remedies.

Our third project involves methodology development of CAD-HPLC in the detection and monitoring pharmaceutical personal products in treated and wastewater.

Selected Publications:
"Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography’,  Dineo Moena, Mathew M. Nindi, Simiso Dube, Analytica Chimica Acta, DOI: 10.1016/j.aca.2011.11.036

“Naturally Quality Control of Harpagophytum procumbens products using High Pressure Liquid Chromatography-Diode Array Detection (HPLC-DAD)”, Samuel Chigome, Mathew Muzi Nindi and Namboole Moses Munkombwe, Nigerian Journal of Natural Products and Medicine, Vol 13, 26-29, (2009)

Determination Of Beta-Lactam Residues in Foodstuffs of Animal Origin using Supported Liquid Membrane Extraction and Liquid Chromatography-Mass Spectrometry”, T. A. M. Msagati, M. M. Nindi, J. Food of Chemistry, 100 (2): 836-844, 2007

Comparative Study of Sample Preparation Methods; Supported Liquid Membrane and Solid Phase Extraction in the Determination of Benzimidazole Anthelmintics in Biological matrices by Liquid Chromatography-Electrospray-Mass Spectrometry Detection” M. M. Nindi and T. A. M. Msagati, Talanta , 69, 243-250, 2006